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Papers in refereed journals

2007

[52]

Chemoselectivity and unusual internal acetal formation in the synthesis of a glycosidation precursor. A. T. Stevens, J. R. Bull and K. Chibale*. Synlett 2007, 3175-3179.

[51]

Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues. C. Biot,* B. Pradines, M-H. Sergeant, J. Gut, P. J. Rosenthal and K. Chibale. Bioorg. Med. Chem Lett. 2007, 17, 6434-6438.

[50]

Synthesis of new 7-chloroquinolinyl thioureas and their biological investigation as potential anti-malarial and anticancer agents. A. Mahajan, S. Yeh, M. Nell, C E J van Rensburg and K. Chibale*. Bioorg. Med. Chem Lett. 2007, 17, 5683-5685.

[49]

Metallocene-based antimalarials: An exploration into the influence of the ferrocenyl moiety on in vitro antimalarial activity in chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. M.A.L. Blackie, P. Beagley, S. L. Croft, H. Kendrick, J. R. Moss and K. Chibale*. Bioorg. Med. Chem. 2007, 15, 6510-6516.

[48]

Application of Multicomponent Reactions to Antimalarial Drug Discovery. Part 3: Discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro. C.C. Musonda, S. Little, V. Yardley and K. Chibale*. Bioorg. Med. Chem Lett. 2007, 17, 4733-4736.

[47]

Antiplasmodial hirsutinolides from Vernonia staehelinoides and their utilization towards a novel simplified pharmacophore. P. Pillay*, R. Vleggaar, V. J. Maharaj, P. J. Smith, C. A. Lategan,. F. Chouteau and K. Chibale. Phytochemistry 2007, 68, 1200-1205.

[46]

Purification of human malaria parasite hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT) using immobilized Reactive Red 120. B. Mbewe*, K. Chibale and D. B. McIntosh. Protein Expression and Purification 2007, 52, 153-158.

[45]

Synthesis and Biological Evaluation of Phenolic Mannich Bases of Benzaldehyde and (thio) semicarbazone derivatives Against the Cystein Protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum. A. Chipeleme, J. Gut, P. J. Rosenthal and K. Chibale*. Bioorg. Med. Chem. 2007, 15, 273-282.