Also known as bilharzia, schistosomiasis is a debilitating disease caused by trematodes and ranks only as second to malaria among parasitic infections. As with malaria, it thrives in tropical and sub-tropical climates where over 90% of the global incidence is recorded. The treatment of Schistosomiasis remains inadequate and especially with the dependence on only one drug, which in itself suffers a number of liabilities such as toxicity and inactivity on immature disease stages.
Through our malaria research program, duo-screening has created opportunities for the repositioning of antimalarial drugs in the Schistosomiasis space. Details of our Schistosomiasis research can be found in our publications [http://www.kellychibaleresearch.uct.ac.za/2020-0]