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In 2012, 3.4 billion people were at risk of malaria, as reported in the WHO Malaria Report of 2013. Malaria remains one of the leading causes of morbidity and mortality in the world, with young children and pregnant woman being the groups most affected. The disease is considered endemic in 104 countries, where Africa has the highest incidence rate (80 % of cases) and the most malaria deaths (90 % of deaths) worldwide.

Over the past few years the high cost, toxicity and resistance to available antimalarial drugs have created a high demand for the discovery of new antimalarial agents with novel modes of action.